ABSTRACT
Objective:To explore the effect of mifepristone combined with methotrexate intracapsular injection on pregnancy at scar site of endogenous cesarean section.Methods:From June 2014 to June 2019, 106 cases of pregnancy at scar site of endogenous cesarean section admitted to Jinhua Maternal and Child Health Hospital were selected in the research.According to the random number table method, the patients were divided into control group and observation group, with 53 cases in each group.The control group received hysteroscopy curettage only, routine anti-infection, curettage under the guidance of B-ultrasound.The observation group was given mifepristone and methotrexate intracapsular injection on the basis of the control group.The clinical effect, recovery time of serum β-HCG, intraoperative blood loss, postoperative complications and hospitalization time were compared between the two groups.Results:The total effective rate of the observation group[92.45%(49/53)] was higher than that of the control group[75.47%(40/53)](χ 2=5.675, P<0.05). The recovery time of β human chorionic gonadotropin (β-HCG) in the observation group[(17.58±2.54)d] was faster than that in the control group[(21.83±4.13)d], and the intraoperative blood loss[(25.42±5.46)mL] was less than that in the control group[(87.93±18.47)mL], the differences were statistically significant ( t=6.381, 23.628, all P<0.05). The incidence of postoperative complications of the observation group (1.89%) was lower than that of the control group (9.43%), but there was no statistically significant difference between the two groups (χ 2=1.590, P>0.05). The hospitalization time of the observation group[(7.83±1.52)d]was shorter than that of the control group[(9.68±2.19)d]( t=5.052, P<0.05). Conclusion:Mifepristone combined with methotrexate intracapsular injection has good clinical effect on endogenous cesarean scar pregnancy.It can accelerate the recovery time of blood β-HCG, which is worthy of clinical reference.
ABSTRACT
OBJECTIVE:To improve the rational and scientific drug purchase quantity planned by hospital pharmacy. METH-ODS:The deficiency in present drug purchase module of hospital information system(HIS)was analyzed;the formula of planned purchase quantity was improved by incremental coefficient method,ABC analysis method and VEN analysis method. The high and low stored values and packaging volume were set to adjust planned drug purchase quantity. Based on the computer program,a one-key-getting procedure was quasi established,and five typical drugs were selected for simulation. RESULTS:Based on previous formula,the parameters representing change trend,incremental coefficient k1 and inventory coefficient k2 were added in new formu-la. The one-key-getting procedure could calculate the quantity of all drugs by simply entering the planning cycle N1 and the safe peri-od N2 of the some category drugs into the system. After simulated operation practice,compared with pre-improvement,the occupa-tion of funds was significantly decreased and the quantity of drug was rounded off according to package in post-improvement. CON-CLUSIONS:Through function improvement of drug purchase module in HIS and the quasi establishment of one-key-getting pur-chase mode,planned drug purchase quantity is more reasonable,scientific and accurate. It ensures the clinical drug supply in time without causing a backlog,and effectively reduces the cost of manpower,material and capital.
ABSTRACT
OBJECTIVE:To explore the idea and method of post-marketing safety reevaluation of TCM injection in our hospi-tal. METHODS:In case-control study,salvianolate for injection was chosen for practice. 1 000 patients with stable angina receiv-ing Salvianolate for injection in our hospital during May 2012-Oct. 2013 were selected as subjects. The occurrence of ADR/ADE were observed and Logistic regression analysis was conducted by using SPSS 20.0 software. RESULTS:The incidence of ADR/ADE was 0.6%,and rare(0.1%-1%). The ADR/ADE were general and mainly manifested as erythra(66.67%). Skin and its ap-pendants were main organs involved in ADR(66.67%). Logistic regression analysis showed that gender,drug combination and age are risk factors of ADR/ADE. CONCLUSIONS:The post-marketing safety reevaluation of TCM injection not only make up for the deficiency of pre-marketing safety evaluation of TCM injection and find out potential delayed and severe ADR/ADE and drug inter-action,but also provide reference for rational drug use in the clinic and guarantee the safe and rational drug use.